Cyrille F. Dunant

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Bone marrow hematopoietic stem cells (HSCs) are crucial to maintain lifelong production of all blood cells. Although HSCs divide infrequently, it is thought that the entire HSC pool turns over every few weeks, suggesting that HSCs regularly enter and exit cell cycle. Here, we combine flow cytometry with label-retaining assays (BrdU and histone H2B-GFP) to(More)
Intratumoral heterogeneity arises through the evolution of genetically diverse subclones during tumor progression. However, it remains unknown whether cells within single genetic clones are functionally equivalent. By combining DNA copy number alteration (CNA) profiling, sequencing, and lentiviral lineage tracking, we followed the repopulation dynamics of(More)
In a classical view of hematopoiesis, the various blood cell lineages arise via a hierarchical scheme starting with multipotent stem cells that become increasingly restricted in their differentiation potential through oligopotent and then unipotent progenitors. We developed a cell-sorting scheme to resolve myeloid (My), erythroid (Er), and megakaryocytic(More)
In this article we explore the tradeoffs of using an internal mesher in a XFEM code. We show that it allows for an optimal enrichement detection scheme, while retaining the ability to have general, well-adapted meshes.We also provide some benchmarks highlighting the considerable gains which can be expected from a well designed architecture. The efficiency(More)
The evolution of cooperation is a fundamental and enduring puzzle in biology and the social sciences. Hundreds of theoretical models have been proposed, but empirical research has been hindered by the generation time of social organisms and by the difficulties of quantifying costs and benefits of cooperation. The significant increase in computational power(More)
Blood cells are organized as a hierarchy with hematopoietic stem cells (HSCs) at the root. The advent of genomic technologies has opened the way for global characterization of the molecular landscape of HSCs and their progeny, both in mouse and human models, at the genetic, transcriptomic, epigenetic, and proteomics levels. Here, we outline our current(More)
Modelling transport and long-term creep in concrete materials is a difficult problemwhen the complexity of the microstructure is taken into account, because it is hard to predict instantaneous elastic responses. In this work, several numerical methods are compared to assess their properties and suitability to model concrete-like microstructures with large(More)
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