Cyriac Abby Philips

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Missense mutations in the presenilin-1 (PS-1) and presenilin-2 (PS-2) genes have been shown to be causes of autosomal dominant Alzheimer's disease (the AD3 and AD4 loci, respectively). Alternative splicing has previously been reported in the PS-1 gene. In this study, elucidation of intron/exon boundary sequences revealed that PS-2 is encoded by 10 coding(More)
In this "nation of associations," organizations are frequently established to serve the common interests of their constituencies. The periodic emergence of associations serving the neurosurgical community is a matter of historical record. However, little attention has been paid to the reasons why these neurosurgical associations have come into being.(More)
This paper shows how n-node, e-edge graphs can be contracted in a mannel ~ similar to the parallel tree contraction algorithm due ~o Miller and Reif. We give an O((n + e)/lgn)-processor deterministic algorithm that contracts a graph in O(lg 2 n) time in the EREW PRAM model. We also give art O(n/lg n)-processor randomized algorithm that with high probability(More)
We present a rare case of spontaneous trans-splenic shunt and intra-splenic collaterals in a patient with liver cirrhosis and portal hypertension. The shunt and presence of cirrhosis and portal hypertension was incidentally detected by abdominal computed tomographic imaging during evaluation for abdominal pain. There has been a single report on the presence(More)
Diabetic Myonecrosis is a rare complication of long-standing Diabetes Mellitus Type 1 and 2. The most likely affected areas are of proximal lower limbs, mostly the quadriceps muscle. The presenting features are myriad and a diagnostic conundrum for the physician. There has been previously mentioned, through few case reports, the classical presentation of(More)
A 19-year-old man presented with painless jaundice for 3 months. He had a 14-year history of recurrent, photosensitive, painful rashes without blistering on exposed areas of the face and hands. Examination revealed icterus, hyperpigmentation, hyperkera-tosis, and leathery texture over affected hands with onyncholysis, loss of lunulae, melanonychia, and firm(More)
Portosystemic collateral formation in cirrhosis plays an important part in events that define the natural history in affected patients. A detailed understanding of collateral anatomy and hemodynamics in cirrhotics is essential to envisage diagnosis, management, and outcomes of portal hypertension. In this review, we provide detailed insights into the(More)
A 52-year-old female without comorbidities presented with dull, aching pain in the right upper quadrant associated with nausea, but not fever, jaundice, anorexia, or abdominal distension. Examination showed tachycardia and mild tenderness in the right upper quadrant. Investigations revealed a normal hemogram with preserved liver function, renal function,(More)
Tumors of the pancreas that contain substantial cystic components include mainly mucinous cystic neoplasm, intraductal papillary mucinous neoplasm, solid pseudopapillary tumor, and cystadenomas (which encompass microcystic, macrocystic/oligocystic, and rare solid serous adenomas). Microcystic adenoma of the pancreas is a tumor that is benign in nature.(More)