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Proteasomes are the main proteases responsible for cytosolic protein degradation and the production of major histocompatibility complex class I ligands. Incorporation of the interferon gamma--inducible subunits low molecular weight protein (LMP)-2, LMP-7, and multicatalytic endopeptidase complex--like (MECL)-1 leads to the formation of immunoproteasomes(More)
Proteasomes degrade endogenous proteins. Two subunits, LMP-2 and LMP-7, are encoded in a region of the major histocompatibility complex (MHC) that is critical for class I-restricted antigen presentation. Mice with a targeted deletion of the gene encoding LMP-7 have reduced levels of MHC class I cell-surface expression and present the endogenous antigen HY(More)
Smartphones, tablets and other mobile platforms typically accommodate bulk data storage with low-cost, FAT-formatted Secure Digital cards. When one uses a mobile device to run a full-system virtual machine (VM), there can be a mismatch between 1) the VM's I/O mixture, security and reliability requirements and 2) the properties of the storage media available(More)
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