Cynthia Prudence

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This report summarizes the scientific content and activities of the annual symposium organized by the Student Council of the International Society for Computational Biology (ISCB), held in conjunction with the Intelligent Systems for Molecular Biology (ISMB) / European Conference on Computational Biology (ECCB) conference in Berlin, Germany, on July 19,(More)
Previously we provided evidence that myosin subfragment 1 (S1) can bind either one (state 1) or two actin monomers (state 2) in solution and in muscle fiber. Here we present results of the kinetics study of binding of S1 to F-actin labeled with fluorescent dye pyrene. A transition from state 1 to state 2 depends on probability that the second actin is free,(More)
The fluorescence properties of tryptophan residues are sensitive to the microenvironment of tryptophan fluorophores in proteins. Therefore, fluorescence characteristics are widely used to study structural transitions in proteins. We have developed algorithms for the decomposition of multi-component protein fluorescence spectra and the correlation of these(More)
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