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A two-step reconstitution system for the generation of ER cargo exit sites from starting ER-derived low density microsomes (LDMs; 1.17 g/cc) is described. The first step is mediated by the hydrolysis of Mg 2 ϩ ATP and Mg 2 ϩ GTP, leading to the formation of a transitional ER (tER) with the soluble cargo albumin, trans-ferrin, and the ER-to-Golgi recycling(More)
Tumor cells utilize glucose as a primary energy source and require ongoing lipid biosynthesis for growth. Expression of DecR1, an auxiliary enzyme in the fatty acid beta-oxidation pathway, is significantly diminished in numerous spontaneous mammary tumor models and in primary human breast cancer. Moreover, ectopic expression of DecR1 in ErbB2/Neu-induced(More)
BACKGROUND AND PURPOSE Phosphorylation of δ opioid receptors (DOP receptors) by cyclin-dependent kinase 5 (CDK5) was shown to regulate the trafficking of this receptor. Therefore, we aimed to determine the role of CDK5 in regulating DOP receptors in rats treated with morphine or with complete Freund's adjuvant (CFA). As μ (MOP) and DOP receptors are known(More)
Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes. Essential role of PKC delta in platelet signalling, alpha llb beta 3 activation and thromboxane A2 release. (2006) Muscarinic acetylcholine receptors mediate oligodendrocyte progenitor survival through Src family kinases and PI3K pathways.(More)
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