Cynthia L. Hunt

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Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly characterized from an integrative perspective. Here spatiotemporal alterations in brain amyloid-β deposition, metabolism, vascular, functional activity at rest, structural properties, cognitive integrity and peripheral proteins levels are characterized in relation to LOAD(More)
Yuetiva Deming1,*, Jian Xia1,2,*, Yefei Cai1, Jenny Lord1,3, Jorge L. Del-Aguila1, Maria Victoria Fernandez1, David Carrell1, Kathleen Black1, John Budde1, ShengMei Ma1, Benjamin Saef1, Bill Howells1, Sarah Bertelsen1, Matthew Bailey4, Perry G. Ridge4, Alzheimer’s Disease Neuroimaging Initiative (ADNI)¶, David Holtzman5,6,7,8, John C. Morris5,6,7,8, Kelly(More)
The Clusterin (CLU) gene, also known as apolipoprotein J (ApoJ), is currently the third most associated late-onset Alzheimer's disease (LOAD) risk gene. However, little was known about the possible effect of CLU genetic variants on AD pathology in brain. Here, we evaluated the interaction between 7 CLU SNPs (covering 95% of genetic variations) and the role(More)
SCUBA-2 is a submillimeter camera being built for the James Clerk Maxwell Telescope in Hawaii. Bringing CCD style imaging to the submillimeter for the first time, with over 10000 pixels, it will provide a revolutionary improvement in sensitivity and mapping speed. We present results of the first tests on a prototype 1280 pixel SCUBA-2 subarray; the full(More)
We report test results for a single pixel antenna-coupled bolometric detector. Our device consists of a dual slot microstrip antenna coupled to an Al/Ti/Au voltage-biased transition edge superconducting bolometer (TES). The coupling architecture involves propagating the signal along superconducting microstrip lines and terminating the lines at a normal(More)
PURPOSE This article offers a discussion about the use of focused ethnography and the community readiness model to study disability at the community level in cross-cultural or international settings. It describes lessons learned when applying these methods to inform community-based disability programming in remote, rural villages in Ladakh, India. METHODS(More)
Mild cognitive impairment (MCI) is a precursor phase of Alzheimer's disease (AD). As current treatments may be effective only at the early stages of AD, it is important to track MCI patients who will convert to AD. The aim of this study is to develop a high performance semi-mechanism based approach to predict the conversion from MCI to AD and improve our(More)
Accurate prediction of Alzheimer's disease (AD) is important for the early diagnosis and treatment of this condition. Mild cognitive impairment (MCI) is an early stage of AD. Therefore, patients with MCI who are at high risk of fully developing AD should be identified to accurately predict AD. However, the relationship between brain images and AD is(More)
We are developing focal plane arrays of bolometric detectors for sub-millimeter and millimeter-wave astrophysics. We propose a flexible array architecture using arrays of slot antennae coupled via low-loss superconducting Nb transmission line to microstrip filters and antenna-coupled bolometers. By combining imaging and filtering functions with transmission(More)