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OBJECT Surgical and medical therapies successfully achieve biochemical remission in the majority of patients with secretory pituitary adenomas. Nevertheless, continued hypersecretion after first-line therapy occurs and requires adjunctive therapy to prevent morbidity and premature mortality. For patients in whom medical and surgical therapy have failed,(More)
A validated quality of life (QOL) measure, the SF-36 questionnaire, was used to assess patients' perception of the impact of a pituitary adenoma, prior to treatment, on his or her physical and mental functioning. Of 270 new patients evaluated for pituitary disease at the University of Virginia Pituitary Clinic, 168 met the criteria for inclusion (pituitary(More)
OBJECTIVE Because acromegaly is an uncommon disorder, epidemiological data regarding the demographics of the disease such as the prevalence of hypogonadism have been limited. In order to derive clinical and epidemiological information, including underlying hormonal factors, regarding hypogonadism in patients with acromegaly, we performed a pilot study(More)
Recordings of force developed simultaneously by four rowers in a good club-standard eight over a 20-min training run were analysed in terms of mean and variability. The average force-time profiles showed small but distinctive differences between rowers that were maintained as force declined through the run. The variability was examined further in terms of(More)
Let k be a field. Then Gaussian elimination over k and the Eu-clidean division algorithm for the univariate polynomial ring k[x] allow us to write any matrix in SL n (k) or SL n (k[x]), n ≥ 2, as a product of elementary matrices. Suslin's stability theorem states that the same is true for the multivariate polynomial ring SL n (k[x 1 ,. .. , x m ]) with n ≥(More)
The problem of the design and effective implementation of multi-dimensional filter banks with prescribed properties is considered. Several algorithms for polyphase matrices factorization are presented. After such a factorization the number of computations may become much lower. The results for the 2-channel FBs are given. For the 3-channel multirate system(More)
Let k be a eld, and let M be a commutative, seminormal, nitely generated monoid, which is torsionfree, cancellative, and has no nontrivial units. J. Gubeladze proved that nitely generated projective modules over kM are free. This paper contains an algorithm for nding a free basis for a nitely generated projective module over kM. As applications one obtains(More)
The problem of the design of effective 2-D and 3-D multirate systems with prescribed properties is considered using tools from commutative algebra. Results for factoring 2-channel polyphase matrices are presented. After such a factorization, the number of computations may be reduced. For a 3-channel multirate system, an algo-rithmic version of Suslin's(More)
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