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Cardiovascular disease remains the leading cause of mortality in westernized countries, despite optimum medical therapy to reduce the levels of low-density lipoprotein (LDL)-associated cholesterol. The pursuit of novel therapies to target the residual risk has focused on raising the levels of high-density lipoprotein (HDL)-associated cholesterol in order to(More)
The prefrontal cortex continues to mature after puberty and into early adulthood, mirroring the time course of maturation of cognitive abilities. However, the way in which prefrontal activity changes during peri- and postpubertal cortical maturation is largely unknown. To address this question, we evaluated the developmental stage of peripubertal rhesus(More)
The purpose of the experiments reported here was to investigate central nervous system effects of commonly prescribed postmenopausal hormone therapies in a primate model, the cynomolgus monkey (Macaca fascicularis). The results of two experiments are reported. In the first, ovariectomized adult cynomolgus monkeys were treated for eight weeks each with oral(More)
Contrary to expectations, a study of 81 adolescent drug and/or alcohol addicts produced results quite similar to those found among an adult addicted population (Griffin-Shelley, 1986). On the Bem Sex-Role Inventory (Bem, 1974), these young people rated themselves, in descending order, Undifferentiated (43.2%), Masculine (23.5%), Androgynous (18.5%), and(More)
The dorsolateral prefrontal cortex matures late into adolescence or early adulthood. This pattern of maturation mirrors working memory abilities, which continue to improve into adulthood. However, the nature of the changes that prefrontal neuronal activity undergoes during this process is poorly understood. We investigated behavioral performance and neural(More)
Basic data on age-related neuroanatomical changes across the juvenile to adult period in nonhuman primates is sparse, and this gap in knowledge is a serious impediment to translational research aimed at understanding brain development across the lifespan. In this study, magnetic resonance images were analyzed for fifteen mother-reared, socially-housed(More)
Executive functions including behavioral response inhibition mature after puberty, in tandem with structural changes in the prefrontal cortex. Little is known about how activity of prefrontal neurons relates to this profound cognitive development. To examine this, we tracked neuronal responses of the prefrontal cortex in monkeys as they transitioned from(More)
Cardiovascular disease (CVD) remains the leading cause of mortality in westernized countries, despite optimum medical therapy to lower LDL cholesterol. The pursuit of novel therapies to target this residual risk has focused on raising levels of HDL cholesterol in order to exploit its atheroprotective effects 1. MicroRNAs have emerged as important(More)
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