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OBJECTIVE To report the clinical features of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in patients < or = 18 years old. METHODS Information was obtained by the authors or referring physicians. Antibodies were determined by immunocytochemistry and enzyme-linked immunosorbent assay (ELISA) using HEK293 cells ectopically expressing NR1. (More)
BACKGROUND AND PURPOSE The purposes of this study were to determine the incidence of neurovascular events as late complications in pediatric patients with brain tumor and to evaluate radiation as a risk factor. METHODS Patients were ascertained using the tumor database of a pediatric tertiary care center. Included patients had a primary brain tumor, age(More)
OPINION STATEMENT Rates of regrowth after resection of subependymal giant cell astrocytoma (SEGA) are low, making surgical resection a successful and permanent therapeutic strategy. In addition to surgical resection of SEGAs, other treatment options now include medications and Gamma Knife™ therapy. Advising patients on medical versus surgical management of(More)
Purpose To evaluate intellectual functioning and the implications of limiting radiation exposure in the four biologically distinct subgroups of medulloblastoma: wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4. Patients and Methods A total of 121 patients with medulloblastoma (n = 51, Group 4; n = 25, Group 3; n = 28, SHH; and n = 17, WNT), who(More)
Embryonal tumors are an aggressive subtype of high-grade, pediatric central nervous system (CNS) tumors often with dismal survival rates. The 5-year survival for highest-risk embryonal tumors may be as low as 10 %. We report feasibility and efficacy from our experience using intravenous (IV) cyclophosphamide concurrently with craniospinal radiation (CSI) in(More)
OBJECTIVE To determine whether severe recurrent headache is a risk factor for neurovascular events in children who received radiation for brain tumors. METHODS This is a retrospective cohort study of children with brain tumors who received cranial irradiation at a large tertiary care center, aged 0-21 years at diagnosis, with initial treatment between(More)
OBJECTIVE To compare cerebral perfusion and diffusion in survivors of childhood posterior fossa brain tumor with neurologically normal controls and correlate differences with cognitive dysfunction. STUDY DESIGN We analyzed retrospectively arterial spin-labeled cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) in 21 patients with(More)
Ty Abel Karen Aboody Roger Abounader Lauren Abrey John Adler Nathalie Agar Manish Aghi Ana Aguilar Manmeet Ahluwala Atique Ahmed Razia Akhtar Brian Alexander George Alexiou Jeffrey Allen David Andrews Ovidiu Andronesi Terri Armstrong Lynn Ashby Anthony Asher Peter Bachert Suzanne Baker Leonora Balaj Yeshavanth Banasavadi-Siddegowda Xuhui Bao Igor Barani(More)
BACKGROUND AND PURPOSE Neurofibromatosis type 1 is associated with increased risk for stroke, cerebral vasculopathy, and neurocognitive deficits, but underlying hemodynamic changes in asymptomatic children remain poorly understood. We hypothesized that children with neurofibromatosis type 1 have decreased cerebral blood flow. MATERIALS AND METHODS(More)
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