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Placental examination can be a useful tool for specifying the etiology, prognosis, and recurrence risk of pregnancy disorders. The purpose of this study was to test the reliability of a predetermined set of placental reaction patterns seen with maternal vascular underperfusion in the hope that this might provide a useful diagnostic framework for practicing(More)
Growth disturbance in the trisomic fetus is believed to be primarily fetal in origin. There has been only sparse description of placental pathology in the third trimester in these fetuses, and therefore the placental role in their growth and development remains unexplored. We performed quantitative morphometric analysis on the placentas of 18 fetuses with(More)
We report eight cases of intrauterine rupture of the dividing membranes in diamniotic twin gestations and the resulting perinatal morbidity and mortality. The poor outcomes associated with these intrauterine amniotic ruptures included fetal and neonatal death secondary to cord entanglement, preterm rupture of the membranes, preterm labor and delivery, and(More)
In a case of Werdnig-Hoffmann disease, we have observed pathologic changes in the neuronal cell bodies of the lateral geniculate nucleus. These changes are similar to those seen in lower motor neurons and dorsal root ganglia. As the lateral geniculate nucleus and its projections are entirely central, this observation raises questions as to the possible(More)
OBJECTIVE To test the hypothesis that histological chorioamnionitis (CA) is not associated with increased risk of early onset intraventricular hemorrhage (IVH). STUDY DESIGN Clinical data were prospectively collected for 62 consecutive neonates born before 28 weeks of gestation. Placental histology for CA was performed by a pathologist unaware of the head(More)
Forty-three cases of microglandular hyperplasia of the cervix seen during a 3.5-year period are reported. The series is unusual in that more than one-half of the patients had no history of oral contraceptive use and three patients were postmenopausal. Additionally, evidence of estrogenic stimulation was present in eight cases. The role of estrogens and(More)
Placental morphologic examination can provide the clinician much information regarding pathogenesis in many problems of pregnancy and newborns. This depends on appropriate examination at the time of delivery, with triage to pathology based on clinical criteria and initial gross examination. The delivery room examination can readily assess gross lesions of(More)