Learn More
FMRP loss of function causes Fragile X syndrome (FXS) and autistic features. FMRP is a polyribosome-associated neuronal RNA-binding protein, suggesting that it plays a key role in regulating neuronal translation, but there has been little consensus regarding either its RNA targets or mechanism of action. Here, we use high-throughput sequencing of RNAs(More)
Structural protein 4.1, which has crucial interactions within the spectrin-actin lattice of the human red cell membrane skeleton, also is widely distributed at diverse intracellular sites in nucleated cells. We previously showed that 4.1 is essential for assembly of functional nuclei in vitro and that the capacity of 4.1 to bind actin is required. Here we(More)
0198-9715/$ see front matter 2011 Elsevier Ltd. A doi:10.1016/j.compenvurbsys.2011.05.003 ⇑ Corresponding author. Tel.: +1 212 772 4658; fax E-mail address: gong@hunter.cuny.edu (H. Gong). 1 Present address: MTA Bus Company, Metropolitan Broadway, New York, NY 10004, United States. Handheld GPS provides a new technology to trace people’s daily travels and(More)
Crustal rocks recrystallized at confining pressures characterized by stabilities of the dense phases coesite and/or diamond are defined as ultrahigh-pressure (UHP) metamorphic rocks. P-T conditions required for the production of these polymorphs, as well as other UHP phase assemblages such as Krich and/or supersilicic clinopyroxene and majoritic garnets,(More)
BACKGROUND We previously described a t(2;11)(p21;q23) chromosomal translocation found in patients with myelodysplasia or acute myeloid leukemia that leads to over-expression of the microRNA miR-125b, and we showed that transplantation of mice with murine stem/progenitor cells overexpressing miR-125b is able to induce leukemia. In this study, we investigated(More)
BACKGROUND Excess adiposity is associated with cardiovascular disease (CVD) risk factors such as hypertension, diabetes mellitus and dyslipidemia. Amongst the various measures of adiposity, the best one to help predict these risk factors remains contentious. A novel index of adiposity, the Body Adiposity Index (BAI) was proposed in 2011, and has not been(More)
We have determined the solution structure of the complex between an arginine-glycine-rich RGG peptide from the human fragile X mental retardation protein (FMRP) and an in vitro-selected guanine-rich (G-rich) sc1 RNA. The bound RNA forms a newly discovered G-quadruplex separated from the flanking duplex stem by a mixed junctional tetrad. The RGG peptide is(More)
OBJECTIVES To investigate the longitudinal patterns of recovery among workers with compensated occupational back injuries. METHODS A longitudinal cohort study, with one-year follow-up via structured telephone interviews, among respondents off work because of "new" back injuries. Self-reported pain intensity was recorded at baseline and at four follow-up(More)
OBJECTIVES To (1) identify all available rehabilitation impact indices (RIIs) based on their mathematical formula, (2) assess the evidence for independent predictors of each RII and (3) propose a nomenclature system to harmonise the names of RIIs. DESIGN Systematic review. DATA SOURCES PubMed and references in primary articles. STUDY SELECTION First,(More)
Summary Insecticide-treated nets have proved successful in the prevention of malaria as a result of both the personal protection with which they provide the sleeper and also the 'mass effect' on the local mosquito population when they are used on a community-wide basis. Personal protection estimates are normally based on comparisons of the numbers of(More)