Cynthia A. Cruickshank

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Seliciclib (CYC202; R-roscovitine) is the first selective, orally bioavailable inhibitor of cyclin-dependent kinases 1, 2, 7 and 9 to enter clinical trial. Preclinical studies showed antitumour activity in a broad range of human tumour xenografts. A phase I trial was performed with a 7-day b.i.d. p.o. schedule. Twenty-one patients (median age 62 years,(More)
In a comparison of assessment methods of severity of depressive illness, the Montgomery-Asberg Scale had, broadly, a performance equal to the Hamilton Scale. The Beck Depression Inventory, it subscale, and the Wakefield Inventory all had overall poor performances and should now be abandoned in research. The two-patient-rated scales were, overall, similar(More)
BACKGROUND Penis cancer is rare and clinical trial evidence on which to base treatment decisions is limited. Case reports suggest that the combination of docetaxel, cisplatin and 5-flurouracil (TPF) is highly active in this disease. METHODS Twenty-nine patients with locally advanced or metastatic squamous carcinoma of the penis were recruited into a(More)
Simplified building models have gained in popularity as a result of their practical applications in model-based predictive control (MPC); however , these models require accurate parameter estimates in order to give meaningful results. To this end, this simulation-based study proposes a recursive parameter estimation methodology — the so-called Ensemble(More)
The performance of 47 patients with Parkinson's disease on a battery of tests of cognition, motor function, disability and mood was compared with the performance of 47 healthy control subjects who were matched to the patients on the basis of age, sex and pre-morbid IQ. An increased prevalence of impairment over a range of cognitive functions was observed in(More)
Demand for space cooling in Canada has significantly increased in the past 20 years, and in conjunction with space heating loads in the winter are placing larger peak loads on the electrical grid. As a result, utilities must increase their generating and transmission capacity to meet the peak annual demand, with much of the capacity going unused for large(More)
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