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Development of Next Generation Stevia Sweetener: Rebaudioside M
TLDR
It is demonstrated that rebaudioside M could be of great interest to the global food industry because it is well-suited for blending and is functional in a wide variety of food and beverage products.
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Small molecule suppression of carbapenem resistance in NDM-1 producing Klebsiella pneumoniae.
TLDR
A 2-aminoimidazole derived small molecule is identified that acts as an antibiotic adjuvant and is able to suppress resistance of a NDM-1 producing strain of K. pneumoniae, able to lower carbapenem minimum inhibitory concentrations by up to 16-fold while exhibiting little bactericidal activity itself.
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Intercepting bacterial indole signaling with flustramine derivatives.
TLDR
DFBr derivatives are found that are 10-1000 times more active than indole itself, demonstrating that the flustramine family of indolic natural products represent a privileged scaffold for the design of molecules to control pathogenic bacterial behavior.
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Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria.
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Isolation and Characterization of a Novel Rebaudioside M Isomer from a Bioconversion Reaction of Rebaudioside A and NMR Comparison Studies of Rebaudioside M Isolated from Stevia rebaudiana Bertoni…
A minor product, rebaudioside M2 (2), from the bioconversion reaction of rebaudioside A (4) to rebaudioside D (3), was isolated and the complete structure of the novel steviol glycoside was…
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Bioconversion of Rebaudioside I from Rebaudioside A
TLDR
This work reports the bioconversion of rebaudioside A to rebaudioide I using a glucosyltransferase enzyme to supply the increasing demand of natural high potency sweeteners to reduce the calories in food and beverages.
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Isolation and Structure Elucidation of Rebaudioside D2 from Bioconversion Reaction of Rebaudioside A to Rebaudioside D
TLDR
Rebaudioside D2 possesses a relatively rare 1→6 sugar linkage, which was discovered by extensive analysis of NMR (1H, 13C, COSY, HSQC-DEPT, HMBC, 1D TOCSY and NOESY) and mass spectral data.
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Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms.
TLDR
Screening for the ability to modulate biofilm formation against strains of Gram-positive and Gram-negative bacteria identified several compounds with low micromolar, non-toxic IC(50) values.
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The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii.
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Indole/triazole conjugates are selective inhibitors and inducers of bacterial biofilms.
TLDR
Structural/function studies revealed that the addition of a bromine atom at the 2-position of the indole/triazole scaffold altered activity against both Gram-negative and Gram-positive bacteria and could transform a biofilm inhibitor into aBiofilm inducer.
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