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PURPOSE Angiogenesis plays an essential role in tumor development, invasion and metastasis. We evaluated the efficacy and safety of dual angiogenesis blockade with bevacizumab and sorafenib in patients with metastatic breast cancer. PATIENTS AND METHODS Patients who had received no more than 2 prior chemotherapy regimens in any setting were treated with… (More)
The objective of this study was to investigate changes of quality and freezability of stallion semen in response to repeated acute treadmill exercise. Ejaculates from 11 stallions were collected, evaluated and frozen weekly during four periods of 4 weeks each defined as before (period 1), during (period 2) and after (periods 3 and 4) intense exercise. In… (More)
Case report of congenital craniolacunia ("Lückenschädel" or lacunar skull) only associated with several noncerebral malformations but lacking the CNS findings usually associated with this condition, such as dysraphism. Presentation and discussion of etiology and prognosis of this anomaly and its differential diagnosis.