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HER-2/neu (neu-N) transgenic mice, which express the nontransforming rat proto-oncogene, develop spontaneous focal mammary adenocarcinomas beginning at 5-6 months of age. The development and histology of these tumors bears a striking resemblance to what is seen in patients with breast cancer. We have characterized the immunological responses to HER-2/neu(More)
Michael Lawman*, Shabnam Eidizadeh, Christopher Selmon, Curtis Kane, Laura Xigacos, Laura Kaufman, Neil Shaw, Pat Lawman St. Joseph’s Children’s Hospital, Tampa, FL, Florida Veterinary Specialists, Tampa, FL, Morphogenesis, Inc., Oldsmar, FL __________________________________________________________________________________ *Correspondence: Michael Lawman,(More)
Total and differential leucocyte counts have been determined by electronic counting techniques in 474, two-to-four-year-old healthy Thoroughbreds in training. The ranges of values observed (particular those for neutrophils and lymphocytes) were narrower than previously described. Absolute and percentage lymphocyte values were significantly decreased with(More)
BACKGROUND To determine the effect of granulocyte colony-stimulating factor (G-CSF) on tumor growth and cisplatin cytotoxicity in human epithelial ovarian cancer. METHODS Six human epithelial ovarian cancer cell lines were treated with media (control) for 24 hr, G-CSF for 24 hr, cisplatin for 24 hr, simultaneous cisplatin and G-CSF for 24 hr, media(More)
The renin response to hypoxia in late gestation fetal sheep has been well characterized. However, the renin response to asphyxia-the combination of hypoxia and hypercapnia-has not been extensively studied. The purpose of this study was to determine 1) the interaction of hypoxia and hypercapnia in the control of renin secretion in late gestation fetal sheep(More)
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