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  • Jeffrey L. Staudinger, Bonnie Goodwin, +10 authors Steven Anthony Kliewer
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2001 (First Publication: 13 March 2001)
  • The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16α-carbonitrile (PCN), which induce cytochrome P450 3A (CYP3A) expression and protect the body fromExpand
  • J Staudinger, Yong Qi Liu, Ajay Madan, Sultan S. M. Habeebu, Curtis D. Klaassen
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 2001 (First Publication: 1 November 2001)
  • Identification and characterization of the pregnane X receptor (PXR) as a key regulator of cytochrome P450 3A (CYP3A) gene expression has led to an increased understanding of the molecular basis ofExpand
  • Susan C N Buist, Nathan J Cherrington, Supratim Choudhuri, Dylan P Hartley, Curtis D. Klaassen
  • Medicine, Chemistry
  • The Journal of pharmacology and experimental…
  • 2002 (First Publication: 1 April 2002)
  • Rat organic anion transporter 1 (Oat1), Oat2, and Oat3, members of the organic anion transporter family, transport some organic anions across cellular membranes. Previously, highest Oat1 and Oat3Expand
  • Lauren M Aleksunes, Curtis D. Klaassen
  • Medicine, Chemistry
  • Drug Metabolism and Disposition
  • 2012 (First Publication: 1 July 2012)
  • The transcription factors aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), pregnane X receptor (PXR), peroxisome proliferator-activated receptor α (PPARα), and nuclear factorExpand