Curt Sigmund

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BACKGROUND Fasting hyperglycemia has been associated with HIV protease inhibitor (PI) therapy. OBJECTIVE To determine whether absolute insulin deficiency or insulin resistance with relative insulin deficiency and an elevated body mass index (BMI) contribute to HIV PI-associated diabetes. DESIGN Cross-sectional evaluation. PATIENTS 8 healthy(More)
OBJECTIVE We evaluated the efficacy and safety of a twice-daily dosage regimen of cisapride 20 mg in relieving the symptoms of mild-moderate gastroesophageal reflux disease (GERD) in patients with moderate intensity heartburn and no history of erosive esophagitis. METHODS After a 2-wk, single-blind, placebo run-in period, 398 patients who continued to(More)
Despite numerous studies it remains controversial whether nitric oxide (NO·) synthesized by neuronal NOS (nNOS) plays an excitatory or inhibitory role in transmission of baroreflex signals in the nucleus tractus solitarii (NTS). In the current studies we sought to test the hypothesis that nNOS is involved in excitation of baroreflex pathways in NTS while(More)
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