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OBJECTIVE We ask whether subjective socioeconomic status (SES) predicts who develops a common cold when exposed to a cold virus. DESIGN 193 healthy men and women ages 21-55 years were assessed for subjective (perceived rank) and objective SES, cognitive, affective and social dispositions, and health practices. Subsequently, they were exposed by nasal(More)
OBJECTIVE It has been hypothesized that people who typically report experiencing negative emotions are at greater risk for disease and those who typically report positive emotions are at less risk. We tested these hypotheses for host resistance to the common cold. METHODS Three hundred thirty-four healthy volunteers aged 18 to 54 years were assessed for(More)
OBJECTIVE Low childhood socioeconomic status (SES) is a risk factor for adult morbidity and mortality primarily attributable to cardiovascular disease. Here, we examine whether childhood SES is associated with adult host resistance to infectious illness, and whether the effect is limited to a critical period of low SES exposure, can be undone by changes in(More)
In this study, magnetic resonance imaging (MRI) was used to define in vivo the effect of experimental functional obstruction of the eustachian tube (ET) on vascular permeability and the development of middle ear (ME) effusion. After collection of baseline data for ME pressure and MRI, the right tensor veli palatini muscle of 10 cynomolgus monkeys was(More)
BACKGROUND Sleep quality is thought to be an important predictor of immunity and, in turn, susceptibility to the common cold. This article examines whether sleep duration and efficiency in the weeks preceding viral exposure are associated with cold susceptibility. METHODS A total of 153 healthy men and women (age range, 21-55 years) volunteered to(More)
IMPORTANCE The study demonstrates the utility of eustachian tube (ET) function (ETF) test results for accurately assigning ears to disease state. OBJECTIVES To determine if ETF tests can identify ears with physician-diagnosed ET dysfunction (ETD) in a mixed population at high sensitivity and specificity and to define the interrelatedness of ETF test(More)
OBJECTIVE To estimate the rate of exchange of selected gases across the middle ear (ME) mucosa and define the exchange limitations. DESIGN At separate sessions, the ME was inflated via the eustachian tube with a bolus of pure nitrogen, carbon dioxide, oxygen, or nitrous oxide, and ME pressures were recorded by tympanometry at selected intervals for up to(More)
OBJECTIVE To investigate the outcome and related factors in pediatric tracheotomy. DESIGN Retrospective chart review. SETTING Tertiary pediatric academic hospital setting. PATIENTS The study included 181 children below the age of 18 years who underwent 185 tracheotomies between 1991 and 1995. MAIN OUTCOMES AND MEASURES Presenting symptoms and signs,(More)
OBJECTIVES To investigate the safety and efficacy of a topical combination of tobramycin and dexamethasone in a primate model of chronic suppurative otitis media (CSOM) and to explore the contribution of the added topical steroid for the treatment of CSOM. DESIGN Blinded, randomized, placebo-controlled trial. SUBJECTS Sixty juvenile cynomolgus monkeys(More)
Calcification of the intervertebral disc is a common occurrence in the adult population, but it is rare in children. However, its radiological and clinical findings are well described in the pediatric age group, with close to 150 publications on record. In contrast, little information is available regarding the histological features of this entity, which(More)