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Elevated Temperature HPLC: Principles and Applications to Small Molecules and Biomolecules
The use of elevated and high temperatures in high performance liquid chromatography (HPLC) is reviewed, encompassing the range ambient to 250 °C and with examples covering separations of both smallExpand
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Capillary array isoelectric focusing with laser-induced fluorescence detection: milli-pH unit resolution and yoctomole mass detection limits in a 32-channel system
We report a multiplexed capillary electrophoresis system employing an array of 32 capillaries with a micromachined sheath-flow cuvette as the detection chamber. The sample streams were simultaneouslyExpand
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Instrumentation for medium-throughput two-dimensional capillary electrophoresis with laser-induced fluorescence detection.
In two-dimensional capillary electrophoresis, a sample undergoes separation in the first dimension capillary by sieving electrophoresis. Fractions are periodically transferred across an interfaceExpand
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Chemical cytometry: the chemical analysis of single cells
The long-term goal of systems biology is to predict the response of an organism to a genetic or environmental change. However, such predictions are extremely challenging for whole organisms, even forExpand
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Interface of an array of five capillaries with an array of one-nanoliter wells for high-resolution electrophoretic analysis as an approach to high-throughput chemical cytometry.
We report a system that allows the simultaneous aspiration of one or more cells into each of five capillaries for electrophoresis analysis. A glass wafer was etched to create an array of 1-nL wells.Expand
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