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Riccardin D, a novel macrocyclic bisbibenzyl, induces apoptosis of human leukemia cells by targeting DNA topoisomerase II
TLDR
It is demonstrated that riccardin D is a novel DNA topo II inhibitor which can induce apoptosis of human leukemia cells and that it has therapeutic potential for both regular and MDR strains of leukemia cells.
Inhibition of Intestinal Adenoma Formation in APCMin/ + Mice by Riccardin D, a Natural Product Derived from Liverwort Plant Dumortiera hirsuta
TLDR
It is suggested that Riccardin D exerts its chemopreventive effect against intestinal adenoma formation through multiple mechanisms including anti-proliferative, apoptotic, anti-angiogenic and anti-inflammatory activity.
1082-39, an analogue of sorafenib, inhibited human cancer cell growth more potently than sorafenib.
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