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Prognostic significance of X-ray cross-complementing group 1 T-77C polymorphism in resected non-small cell lung cancer.
OBJECTIVE A novel T-77C polymorphism in the promoter region of the DNA repair gene X-ray cross-complementing group 1 (XRCC1) may modulate its transcription to increase the risk of lung cancer. Here,Expand
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Global methylation silencing of clustered proto-cadherin genes in cervical cancer: serving as diagnostic markers comparable to HPV
Epigenetic remodeling of cell adhesion genes is a common phenomenon in cancer invasion. This study aims to investigate global methylation of cell adhesion genes in cervical carcinogenesis and toExpand
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Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/β-TrCP/β-catenin pathways in lung cancer
Growth-arrest-specific 7 (GAS7) belongs to a group of adaptor proteins that coordinate the actin cytoskeleton. Among human GAS7 isoforms, only GAS7C possesses a Src homology 3 domain. We report hereExpand
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Abstract B64: Conglomerate methylation silencing of clustered proto-cadherin genes in the course of cervical carcinogenesis
Objective: A common phenomenon in cancer invasion involves global epigenetic remodeling of cell adhesion genes. Taking the advantage of the discrete spectrum of lesions in cervical carcinogenesis,Expand