Cristy M Lewis

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BACKGROUND The cellular mechanisms regulating branching and growth of the intersegmental vessels (ISVs) are not well understood. We have carried out studies demonstrating that Hedgehog (Hh) signaling is a major regulator of intersomitic vessel growth. RESULTS Inhibition of Hh activity by cyclopamine completely blocks formation of intersomitic vessels in(More)
Cancers often arise within an area of cells (e.g. an epithelial patch) that is predisposed to the development of cancer, i.e. a "field of cancerization" or "field defect." Sporadic colon cancer is characterized by an elevated mutation rate and genomic instability. If a field defect were deficient in DNA repair, DNA damages would tend to escape repair and(More)
AIM To investigate the close parallels between our novel diet-related mouse model of colon cancer and human colon cancer. METHODS Twenty-two wild-type female mice (ages 6-8 wk) were fed the standard control diet (AIN-93G) and an additional 22 female mice (ages 6-8 wk) were fed the control diet supplemented with 0.2% deoxycholic acid [diet + deoxycholic(More)
A program has been initiated to study the distribution of lincosaminides and their biologically active metabolites in the whole animal. Using bioautographic tic analysis, profiles of orally administered clindamycin and its metabolic products in the gastrointestinal tract, liver, blood, kidney and carcass of Sprague-Dawley rats have been constructed. The(More)
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