Cristobal Barrenechea

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BACKGROUND Previously studies have indicated that the insulin receptor substrate-1 (IRS-1) Gly972Arg (G972R) polymorphism is associated with polycystic ovary syndrome (PCOS). We examined the possible association between G972R common variant of the IRS-1 gene and PCOS in Southern Chilean women with PCOS and controls. METHODS A total of 50 women with PCOS(More)
The lateral septum receives the most important afferents from the hippocampus, has been proposed to contribute to theta (theta) rhythm generation. Our aim was to study the membrane and circuital properties of lateral septum neurons and their relationship with hippocampal rhythms. Extra- and intracellular recordings (n=81) were obtained in(More)
Spontaneous activity and responses to sensory stimulation in ventrobasal (VB) thalamic neurons were studied in barbiturate-anesthetized rats through intracellular recordings. The recordings were carried out with micropipettes filled with K acetate KCl plus horseradish peroxidase (HRP), our KCl plus biocytin. Two types of spontaneous depolarizing events were(More)
Transmembrane potentials from medial septal and diagonal band of Broca (MS-DBB) neurons and hippocampal field activity were recorded in curarized and urethanized rats. MS-DBB cells were studied during large amplitude irregular activity and during hippocampal θ rhythm, elicited by either sensory (i.e. stroking the fur on the animal's back) or electrical(More)
Hepatic encephalopathy is mainly caused by an excess of ammonium ions. Among other effects, glutamate transmission in the brain is impaired, and thereof, neuronal function in multiple systems is affected. We investigated in rats the effect of diet induced hyperammonemia in the entorhinal cortex, a well known glutamatergic pathway to the dentate gyrus, by(More)
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