Cristina Worm Weber

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Hyper-IgM (HIGM) syndrome is a heterogeneous group of disorders characterized by normal or elevated serum IgM levels associated with absent or decreased IgG, IgA and IgE. Here we summarize data from the HIGM syndrome Registry of the Latin American Society for Immunodeficiencies (LASID). Of the 58 patients from 51 families reported to the registry with the(More)
CD40 ligand (CD40L) deficiency or X-linked hyper-IgM syndrome (X-HIGM) is a well-described primary immunodeficiency in which Pneumocystis jiroveci pneumonia is a common clinical feature. We have identified an unusual high incidence of fungal infections and other not yet described infections in a cohort of 11 X-HIGM patients from nine unrelated Brazilian(More)
Dietary fiber may influence mineral status of chicks. Wheat bran, corn bran, soy bran, oat hulls, rice bran, and cellulose, were formulated into diets and fed to chicks for 4 weeks. Fiber-added diets contained additional 6% dietary fiber from the fiber sources. Body weights and feed intakes were recorded. Livers and tibias were analyzed for copper, zinc,(More)
BACKGROUND Patients with X-linked hyper-IgM syndrome (X-HIGM) due to CD40 ligand (CD40L) mutations are susceptible to fungal pathogens; however, the underlying susceptibility mechanisms remain poorly understood. OBJECTIVE To determine whether monocyte-derived dendritic cells (DCs) from patients with X-HIGM exhibit normal responses to fungal pathogens. (More)
Insoluble fiber fractions from raw and extruded oat, rice and wheat brans were isolated and phytate removed. In vitro mineral binding studies were performed utilizing copper (Cu2+), calcium (Ca2+) and zinc (Zn2+) ions, which were added individually to enzymatically treated (Prosky et al., 1985), acid washed insoluble fiber residues from oat, rice and wheat(More)