Cristina Satriano

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Poly(ADP-ribose) polymerases (PARPs) are recognized as key regulators of cell survival or death. PARP-1 is essential to the repair of DNA single-strand breaks via the base excision repair pathway. The enzyme may be overactivated in response to inflammatory cues, thus depleting cellular energy pools and eventually causing cell death. Accordingly, PARP-1(More)
Using techniques of tissue engineering, synthetic substitutes can be applied for the repair and regeneration of damaged bone. It has been found that material surface properties are crucial for cell adhesion and spreading, i.e. cell activities that are related directly to the ability of osteoblasts to proliferate. This fact has promoted the strategy of(More)
A very peculiar case of differential cell response towards polysiloxane surfaces of very similar composition is investigated. Poly(hydroxymethylsiloxane) (PHMS) surfaces treated either by O(2)-plasma or 6 keV Ar(+)-beams have been used to test the adhesion, proliferation and spreading of human fibroblasts. The surface chemical structure and nanomorphology(More)
[1] We investigate the effect of extended faulting processes and heterogeneous wave propagation on the early warning system capability to predict the peak ground velocity (PGV) from moderate to large earthquakes occurring in the southern Apennines (Italy). Simulated time histories at the early warning network have been used to retrieve early estimates of(More)
In the present paper, we report the study of the adsorption behavior of a model protein such as human serum albumin (HSA) onto surfaces of a-SiC:H and a-C:H thin films deposited by using the plasma-enhanced chemical vapor deposition (PECVD) technique. The surface composition and surface energy of the various substrates as well as the evaluation of the(More)
In this study, poly-epsilon-caprolactone (PCL) membranes were modified with the cell adhesive peptide RGD by chemical immobilization technique. The roughness and hydrophilicity were increased after RGD immobilization and an improved cell attachment was observed.
The adsorption process of albumin, lysozyme and lactoferrin was investigated onto polymer surfaces, both hydrophobic and hydrophilic treated by oxygen-plasma. In particular thin films of polyhydroxymethylsiloxane (about 90 degrees of static water contact angle) were converted by oxygen plasma treatments at reduced pressure into hydrophilic SiO(x) phases(More)
Angiogenin (ANG), a member of the secreted ribonuclease family, is a potent angiogenesis stimulator that interacts with endothelial cells inducing a wide range of responses. Metal ions dyshomeostasis play a fundamental role in the onset of neurodegenerative diseases, in particular copper that is also involved in angiogenesis processes. It is known that(More)
The influence of the surface chemical structure and related physicochemical properties on the adhesion of P. aeruginosa has been studied for moderately hydrophobic polymers and for hydrophilic surfaces obtained by O2-plasma treatments and 50 keV Ar+ beam irradiation of poly(hydroxymethylsiloxane) and poly(ethyleneterephthalate). The surface chemical(More)
The ability to control cell proliferation/differentiation, using material surface, is a main goal in tissue engineering. The objective of this study was to evaluate the attachment, proliferation and differentiation to the osteoblastic phenotype of human marrow stromal cells (MSC) when seeded on poly-epsilon-caprolactone (PCL) thin films before and after(More)