Cristina Piacenza

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Primary sarcomas of the great vessels are very rare neoplasms and only a few cases have been reported. They are divided into the two broad categories of intimal or luminal and mural sarcomas. We analysed eight advanced high-grade sarcomas originating from major vessels (seven intimal and one mural sarcoma) by means of immunohistochemistry and FISH analysis(More)
Sir, Vlahovic et al, provided evidence of effectiveness of Imatinib treatment in PDGFRB-overexpressing human lung adenocarcinoma xenografts grown in nude mice. In this preclinical model, the effectiveness of the drug is related to decrease in interstitial fluid pressure (IFP), decrease of phosphorylated PDGFRB and VEGF expression and improvement of(More)
Gastrointestinal stromal tumors (GISTs) are characterized by the presence of activating mutations affecting the c-Kit or the PDGFRA gene. Although these mutations are mutually exclusive, their proteins are coexpressed in many GISTs with various modulations of immunostaining depending on which gene is mutated. CD117 expression is currently considered a(More)
MSC (mesenchymal stromal cells) can differentiate into renal adult cells, and have anti-inflammatory and immune-modulating activity. In the present study, we investigated whether MSC have protective/reparative effects in anti-Thy1 disease, an Ab (antibody)-induced mesangiolysis resulting in mesangioproliferative nephritis. We studied five groups of rats:(More)
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