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Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in vivo
Experimental autoimmune encephalomyelitis (EAE), an animal model for human multiple sclerosis, is characterized by demyelination, inflammation and neurodegeneration of CNS in which free radicals playExpand
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Efects of growth hormone and cadmium on the transcription regulation of two metallothionein isoforms
The effect of growth hormone (GH) and cadmium (Cd) on metallothionein (MT) expression was investigated in hepatoma cells. In fish the constitutive isoform MT-B and the metal-responsive MT-A areExpand
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Heavy metal and growth hormone pathways in metallothionein regulation in fish RTH-149 cell line.
Interference between heavy metals and growth hormone (GH) on cell signaling has been previously demonstrated in fish cells. This study was aimed at assessing their effects on expression of theExpand
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Expression of antioxidant molecules after peripheral nerve injury and regeneration
Oxidative stress is considered to be one of the main causes of neural damage after injury. However, little is known about the changes in mRNA expression of antioxidant molecules that occur afterExpand
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In vitro effects of simulated microgravity on Sertoli cell function
Abstract With the advent of space flights questions concerning the effects of microgravity (0×G) on human reproductive physiology have received great attention. The aim of this study was to evaluateExpand
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Expression of antioxidant defense and poly(ADP‐ribose) polymerase‐1 in rat developing Sertoli cells
Sertoli cells play an essential role in the development of a functional testis. ROS (reactive oxygen species) are normally produced by the developing testicular cells and may be dangerous toExpand
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PARP-I and p53 expression in Sertoli cell during rat ontogenesis
Poly ADP-ribose polymerase-I (PARP-I), a nuclear I I 3-kDa Zinc-finger protein, catalyze poly ADP-ribosilation reactions and is involved in many physiological and pathological conditions such as cellExpand
PTMLIF MODEL OF CHEMBL PRECLINICAL ASSAYS OF VIT D DERIVATIVES VS. SINGLE NUCLEOTIDE POLYMORPHISM (SNP) DATA
The vitamin D receptor is a common target for various drugs, and is of great interest due to the protective function that this vitamin exerts on the body. The presence of single nucleotideExpand