The effect of pregnancy on seizure frequency was monitored prospectively in 136 pregnancies of 122 epileptic women. Pregnancy did not influence the seizure frequency in 68 pregnancies (50%). In 50 pregnancies (37%) the number of seizures increased during pregnancy or puerperium. The seizure frequency decreased in 18 pregnancies (13%). In 34 out of 50… (More)
Do outcome measures used in neurological clinical research realistically represent the needs and the expectations of patients and their care givers?
The effects of an oral enteric-coated preparation (VAL 579 capsules) of sodium valproate (VPA) were compared with those of conventional oral and rectal preparations in 24 epileptic patients. Enteric-coated capsules are useful for avoiding gastric intolerance to VPA. Plasma VPA level peaks after the enteric- coated form were later than after other forms. The… (More)