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BACKGROUND & AIMS CD3(-) non-T lymphocytes constitute the second most abundant lymphoid subset in the human small-bowel epithelium, and these CD3(-) intraepithelial lymphocytes are virtually absent in active celiac disease. Phenotypically, they resemble natural killer cells and have been termed natural killer-like intraepithelial lymphocytes. Because of the(More)
UNLABELLED Permanent changes in intestinal intraepithelial lymphocytes have been observed in coeliac patients. The aim of this investigation was to study small intestinal intraepithelial lymphocytes by using flow cytometry and to evaluate its diagnostic value in coeliac disease. Three-colour flow cytometry analyses were performed on isolated epithelial(More)
Intestinal intraepithelial lymphocytes (i-IEL) represent one of the largest, non-organized lymphoid population in the body. They are located outside the epithelial basement membrane among the mucosal epithelial cells. We, and previously other groups, have reported the presence of a CD7+CD3-IEL subset in the epithelium of human small intestine. This subset(More)
This case report points out the rarity of intramural duodenal haematomas after intestinal biopsy in children and serves as a reminder to paediatric endoscopists to be aware of this complication. A 4-year-old girl with short stature and increased anti-gliadin antibodies and no history of bleeding disorders underwent upper gastrointestinal endoscopy to obtain(More)
Intraepithelial lymphocytes (IEL) represent a heterogeneous cellular compartment of unknown functions and controversial ontogeny. Previous observations in humans indicate that the majority of IEL subsets express the CD3 complex associated with either the alphabeta or the gammadelta T-cell receptor components, and describe the characteristic increase of(More)
BACKGROUND AND OBJECTIVES Hepatitis E virus (HEV) infection usually causes an acute self-limited disease. HEV is associated with feces-contaminated drinking water, but other vectors, such as blood, are possible. The aim of this study was to investigate the prevalence of HEV in blood donors and in two groups at high risk of parenteral infections, namely,(More)
BACKGROUND AND OBJECTIVES Hepatitis E virus (HEV) infection usually causes acute self-limited disease. HEV is associated with faecal-contaminated drinking water, but other vectors, such as blood, are possible. The aim of this study was to investigate the prevalence of HEV in blood donors and in two groups at high risk for parenteral infections, namely,(More)
Gastrointestinal symptoms in relation to the ingestion of proteins are common but only in the case of sensitisation to cows' milk protein, soy, or gluten have alterations in the function and structure of the small-intestine been reported. We describe 3 children with cows' milk protein intolerance and associated enteropathy related to fish, rice, and(More)