Cristin M. Galardi

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Bile acids repress the transcription of cytochrome P450 7A1 (CYP7A1), which catalyzes the rate-limiting step in bile acid biosynthesis. Although bile acids activate the farnesoid X receptor (FXR), the mechanism underlying bile acid-mediated repression of CYP7A1 remained unclear. We have used a potent, nonsteroidal FXR ligand to show that FXR induces(More)
Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target Abstract The liver X receptors ␣ and ␤ (LXR ␣ and LXR ␤) have been shown to play important roles in lipid homeosta-sis in liver and macrophages, however, their function in adi-pose tissue is not well defined. Both LXRs are highly(More)
A macrocycle provides diverse functionality and stereochemical complexity in a conformationally preorganized ring structure, and it occupies a unique chemical space in drug discovery. However, the synthetic challenge to access this structural class is high and hinders the exploration of macrocycles. In this study, efficient synthetic routes to macrocyclized(More)
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