Cristiana Ferreira Alves de Brito

  • Citations Per Year
Learn More
The dependence of Plasmodium vivax on invasion mediated by Duffy binding protein (DBP) makes this protein a prime candidate for development of a vaccine. However, the development of a DBP-based vaccine might be hampered by the high variability of the protein ligand (DBP(II)), known to bias the immune response toward a specific DBP variant. Here, the(More)
BACKGROUND Plasmodium vivax infection is characterized by a dormant hepatic stage, the hypnozoite that is activated at varying periods of time after clearance of the primary acute blood-stage, resulting in relapse. Differentiation between treatment failure and new infections requires characterization of initial infections, relapses, and clone multiplicity(More)
Genomic, transcriptomic, proteomic, and metabolomic projects exemplify the "omics" era, and have significantly expanded available data for biomedical research. Recently, next generation sequencing technologies have even more greatly expanded DNA and RNA information. The present challenge is mining this information to obtain meaningful data such as that(More)
Denise Anete Madureira de Alvarenga, MSc, Anielle de Pina-Costa, PhD, Patrı́cia Brasil, MD, PhD, Cristiana Ferreira Alves de Brito, PhD* and Cláudio Tadeu Daniel-Ribeiro, MD, PhD* Laboratório de Malária, Centro de Pesquisas René Rachou Fiocruz, Belo Horizonte, Minas Gerais, Brazil; Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz Fiocruz, Rio de(More)
The genetic manipulation of mosquito vectors is an alternative strategy in the fight against malaria. It was previously shown that bee venom phospholipase A2 (PLA2) inhibits ookinete invasion of the mosquito midgut although mosquito fitness was reduced. To maintain the PLA2 blocking ability without compromising mosquito biology, we mutated the(More)
  • 1