Cristian Ferretti

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RATIONALE Several lines of evidence have indicated that the central histaminergic system might be involved in learning and memory OBJECTIVES The aim of the present study was to ascertain the impact on memory processes of putative histaminergic-cholinergic interactions in the nucleus basalis magnocellularis (NBM) of the rat. METHODS The effects of(More)
In 2], Reiter presents a formalism for database updates speciication. He uses the \situation calculus", that is, many-sorted rst-order languages for representing knowledge about dynamically changing worlds that evolve through diierent states when actions are executed. In these worlds, properties of their objects depend on the current state of the world.(More)
The mnemonic performances of male and female rats were compared in an object recognition test. Females were still able to recognize a previously identified object after a 90-min between-trial interval, compared with only 60 min in the males. Because histamine (HA) involvement in memory processes has been strongly suggested, the effect of H3-HA autoreceptor(More)
In this paper we describe SCDBR, a system that is able to reason automatically from specifications of database updates written in the situation calculus, a first–order language originally proposed by John McCarthy for reasoning about actions and change. The specifications handled by the system are written in the formalism proposed by Ray Reiter for solving(More)
The role of the histamine (HA) H3 receptor (estimated by binding of [3H]N-alpha-methyl HA in the brain cortex) in the response of male rats to four types of stress was evaluated: acute weak foot-shock stress (0.5 mA x 1 s x 5 times), acute intense foot-shock stress (1mA x 10 s x 5 times), acute restraint stress (60 min at 24 degrees C) and chronic variate(More)
The triphenylethylene antiestrogen tamoxifen has been shown previously to inhibit both calmodulin and protein kinase C activities, which are involved in the control of cell proliferation. We have studied the effect of several derivatives of the triphenylethylene antiestrogen family on the inhibition of both calmodulin-dependent cyclic adenosine(More)
Changes in the baseline and in the 40 mM K+-evoked release of histamine from hypothalamus slices were compared in male and female rats aged 2, 6, 12, 18, and 24 months. The baseline release declined in the 12-, 18-, and 24-month males. In contrast, the K+-evoked release remained constant in the males, but in the females it decreased in animals more than 2(More)
Since estradiol (E2) either increases or reduces the number of dopamine receptors in the corpus striatum of adult rats, depending on the dose and length of administration, the sensitivity of the two receptor subpopulations (D1 and D2) to E2 during ontogenesis was investigated. Rats of both sexes received either 10 micrograms/kg E2 for 3 days or 50(More)
In this study we compared the effects of systemic administration of haloperidol (HAL), a typical dopaminergic antagonist and of domperidone (DOM), a dopamine (DA) receptor blocker which does not cross the blood brain barrier but has a potency similar to HAL at DA receptors, on hypothalamic and striatal DA system turnover (evaluated by means of HVA and DOPAC(More)