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BACKGROUND Hypoxic niches in solid tumors harbor therapy-resistant cells. Hypoxia-activated prodrugs (HAPs) have been designed to overcome this resistance and, to date, have begun to show clinical efficacy. However, clinical HAPs activity could be improved. In this study, we sought to identify non-pharmacological methods to acutely exacerbate tumor hypoxia(More)
Analysts spend a disproportionate amount of time with financial data curation before they are able to compare company performances in an analysis. The Extensible Business Reporting Language (XBRL) for annotating financial facts is suited for automatic processing to increase information quality in financial analytics. Still, XBRL does not solve the problem(More)
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