Craig T. Morita

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CDlb restricts the response of human CD4−8−T lymphocytes to a microbial antigen

Steven A. Porcelli, Craig T. Morita, Michael B Brenner
Nature
1992

MOLECULES encoded by the human GDI locus on chromosome 1 (ref. 33) are recognized by selected CD4−8− T-cell clones expressing either αβ or γδ T-cell antigen receptors1,2. The known structural… (More)

Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells.

Craig T. Morita, Evan M. Beckman, +5 authors Michael B Brenner
Immunity
1995

Human V gamma 2V delta 2+ T cells recognize mycobacterial nonpeptide antigens, such as isopentenyl pyrophosphate, and their synthetic analogs, such as monoethyl phosphate, through a TCR-dependent… (More)

Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vgamma2Vdelta2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens.

Craig T. Morita, Chenggang Jin, Ghanashyam Sarikonda, Hong Wang
Immunological reviews
2007

Human Vgamma2Vdelta2 T cells play important roles in mediating immunity against microbial pathogens and have potent anti-tumor activity. Vgamma2Vdelta2 T cells recognize the pyrophosphorylated… (More)

Natural and synthetic non-peptide antigens recognized by human gamma delta T cells.

Craig T. Morita, Yoko Tanaka, Edward Nieves, Michael B Brenner, Barry R. Bloom
Nature
1995

T lymphocytes express either alpha beta or gamma delta T-cell receptor heterodimers. Most alpha beta T cells recognize antigenic peptides bound to major histocompatibility complex molecules but the… (More)

MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function.

Hiranmoy Das, Veronika Groh, +4 authors Jack F. Bukowski
Immunity
2001

Vgamma2Vdelta2 T cells comprise 2%-5% of human peripheral blood T cells, recognize ubiquitous nonpeptide antigens, and expand up to 50-fold during microbial infection. It is not clear why these… (More)

The Syk family of protein tyrosine kinases in T-cell activation and development.

Danny Chu, Craig T. Morita, Arthur Weiss
Immunological reviews
1998

The processes of T-cell development and activation employ similar immature and mature receptors as well as similar signal transduction pathways to achieve different outcomes. Many signaling molecules… (More)

Recognition of a lipid antigen by GDI-restricted αβ+ T cells

MAJOR histocompatibility complex (MHC) class I and class II molecules bind immunogenic peptides and present them to lymphocytes bearing the αβ T-cell antigen receptor (TCR)14. An analogous… (More)

Human gamma delta T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity.

Jack F. Bukowski, Craig T. Morita, Michael B Brenner
Immunity
1999

Approximately 4% of peripheral blood T cells in humans express a T cell receptor with markedly restricted germline gene segment usage (V gamma 2 V delta 2). Remarkably, these T cells expand 2- to… (More)

V gamma 2V delta 2 TCR-dependent recognition of non-peptide antigens and Daudi cells analyzed by TCR gene transfer.

Jack F. Bukowski, Craig T. Morita, Yoshimasa Tanaka, Barry R. Bloom, Michael B Brenner, H Band
Journal of immunology
1995

The predominant subpopulation of gamma delta T cells in human peripheral blood expresses TCR V region genes V gamma 2 paired with V delta 2. Previous studies have shown that these V gamma 2V delta 2+… (More)

Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infections.

Y. T. Shen, Dejiang Zhou, +16 authors Z Chen
Science
2002

To examine the role of T cell receptor (TCR) in gammadelta T cells in adaptive immunity, a macaque model was used to follow Vgamma2Vdelta2+ T cell responses to mycobacterial infections. These… (More)

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