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BACKGROUND In high-risk pregnant women, noninvasive prenatal testing with the use of massively parallel sequencing of maternal plasma cell-free DNA (cfDNA testing) accurately detects fetal autosomal aneuploidy. Its performance in low-risk women is unclear. METHODS At 21 centers in the United States, we collected blood samples from women with singleton(More)
OBJECTIVE To evaluate our experience with the "pelvic pressure pack," a surgical technique for controlling posthysterectomy bleeding. METHODS This is an observational descriptive report of cases collected by the authors during the years 1968-2006. Packs were constructed of various materials (eg, pillow cases, gauze sheets, plastic X-ray cassette drapes,(More)
OBJECTIVE To identify a reference range for placental growth factor (PlGF) in normotensive women without symptoms or signs of preeclampsia. STUDY DESIGN Comprising the study cohort were 247 term pregnancies without preeclampsia or adverse neonatal outcomes from 16 sites in the US and Canada. Serial plasma samples were collected in 6 gestational age (GA)(More)
AIM To compare the efficacy and safety of patient-controlled fentanyl iontophoretic transdermal system (ITS) with morphine intravenous (i.v.) patient-controlled analgesia (PCA) for pain management following gynecological surgery. METHODS Two-open-label, multicenter, randomized, active-controlled, parallel-group studies (n = 1142) were conducted that(More)
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