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We explored the consequences for learning through interaction with an educational microworld called Electric Field Hockey (EFH). Like many mi-croworlds, EFH is intended to help students develop a qualitative understanding of the target domain, in this case, the physics of electrical interactions. Through the development and use of a computer model that(More)
The pathophysiology of burning mouth disorder (BMD) is not clearly understood, but central neuropathic mechanisms are thought to be involved. The aim of this study was to gain insight into the pathophysiology associated with BMD by using functional magnetic resonance imaging (fMRI). Areas of brain activation following thermal stimulation of the trigeminal(More)
We report a small yet detailed study where we recorded students completing an object-oriented programming exercise in the context of a CS2 course using Python. All students struggled while completing the assignment, most notably experiencing difficulties with parameters and referencing elements with object-dot notation. While previous research has(More)
We examine two approaches for evaluating category membership within an information taxonomy: card sorting and a simple statistical approach based on the word frequencies of content items. To assess these two approaches, we used card sorting methods to develop a category structure for a web site. Metrics from the card sorting were obtained to predict(More)
OBJECTIVE JC virus (JCV) seropositivity is a risk factor for progressive multifocal leukoencephalopathy (PML) in patients on natalizumab. Accordingly, the JCV serological antibody test is of paramount importance in determining disease risk. METHODS We tested the accuracy of the JCV serum antibody test by comparing the results of JCV serology to JCV(More)
The miR-15/107 family comprises a group of 10 paralogous microRNAs (miRNAs), sharing a 5' AGCAGC sequence. These miRNAs have overlapping targets. In order to characterize the expression of miR-15/107 family miRNAs, we employed customized TaqMan Low-Density micro-fluid PCR-array to investigate the expression of miR-15/107 family members, and other selected(More)
BACKGROUND For adults with chest pain, the electrocardiogram (ECG) and measures of serum biomarkers are used to screen and diagnose myocardial necrosis. These measurements require time that can delay therapy and affect prognosis. Our objective was to investigate the feasibility and utility of saliva as an alternative diagnostic fluid for identifying(More)
Rat pheochromocytoma (PC12) cells differentiated with nerve growth factor (Nd-PC12) were used to investigate the establishment of a non-productive herpes simplex virus type 1 (HSV-1) infection that is reversible. The results of this work are as follows: (i) Nd-PC12 cultures could be maintained as long term (>7 weeks) non-dividing cultures only when plated(More)