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We explored the consequences for learning through interaction with an educational microworld called Electric Field Hockey (EFH). Like many mi-croworlds, EFH is intended to help students develop a qualitative understanding of the target domain, in this case, the physics of electrical interactions. Through the development and use of a computer model that(More)
The pathophysiology of burning mouth disorder (BMD) is not clearly understood, but central neuropathic mechanisms are thought to be involved. The aim of this study was to gain insight into the pathophysiology associated with BMD by using functional magnetic resonance imaging (fMRI). Areas of brain activation following thermal stimulation of the trigeminal(More)
A computational model of a user navigating Web pages was used to identify factors that affect Web site usability. The model approximates a typical user searching for specified target information in architectures of varying menu depth. Search strategies, link ambiguity, and memory capacity were varied and model predictions compared to human user data. A good(More)
We examine two approaches for evaluating category membership within an information taxonomy: card sorting and a simple statistical approach based on the word frequencies of content items. To assess these two approaches, we used card sorting methods to develop a category structure for a web site. Metrics from the card sorting were obtained to predict(More)
OBJECTIVE JC virus (JCV) seropositivity is a risk factor for progressive multifocal leukoencephalopathy (PML) in patients on natalizumab. Accordingly, the JCV serological antibody test is of paramount importance in determining disease risk. METHODS We tested the accuracy of the JCV serum antibody test by comparing the results of JCV serology to JCV(More)
The miR-15/107 family comprises a group of 10 paralogous microRNAs (miRNAs), sharing a 5' AGCAGC sequence. These miRNAs have overlapping targets. In order to characterize the expression of miR-15/107 family miRNAs, we employed customized TaqMan Low-Density micro-fluid PCR-array to investigate the expression of miR-15/107 family members, and other selected(More)
Rat pheochromocytoma (PC12) cells differentiated with nerve growth factor (Nd-PC12) were used to investigate the establishment of a non-productive herpes simplex virus type 1 (HSV-1) infection that is reversible. The results of this work are as follows: (i) Nd-PC12 cultures could be maintained as long term (>7 weeks) non-dividing cultures only when plated(More)