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Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data.
Clinical investigations evaluating the metabolic consequences in individuals expressing the CYP2C9*2, *3, *4, *5, or *6 alleles are required before large-scale clinical genotyping can be recommended.
Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice.
The data indicate a central role for EETs in tumorigenesis, offering a mechanistic link between lipid signaling and cancer and emphasizing the critical importance of considering possible effects of EET-modulating drugs on cancer.
Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation.
Vasopressin: a new target for the treatment of heart failure.
Genetic Variation in Soluble Epoxide Hydrolase (EPHX2) and Risk of Coronary Heart Disease: An Atherosclerosis Risk in Communities (ARIC) Study
Genetic variation in E PHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene.
Activation of the Acute Inflammatory Response Alters Cytochrome P450 Expression and Eicosanoid Metabolism
- K. N. Theken, Yangmei Deng, M. Kannon, T. M. Miller, S. Poloyac, Craig R. Lee
- Biology, MedicineDrug Metabolism and Disposition
- 1 January 2011
It is demonstrated that acute activation of the innate immune response alters P450 expression and eicosanoid metabolism in mice in an isoform, tissue, and time-dependent manner and whether therapeutic restoration of the functional balance between the P450 epoxygenase and ω-hydroxylase pathways is an effective anti-inflammatory strategy.
Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia‐reperfusion injury in isolated mouse heart
It is demonstrated that increased ROS generation and enhanced DiHOME synthesis by endothelial CYP2C8 impair functional recovery and mask the beneficial effects of increased EET production following I/R.
Tolbutamide, Flurbiprofen, and Losartan as Probes of CYP2C9 Activity in Humans
- Craig R. Lee, J. Pieper, A. Hinderliter, R. Frye, J. Blaisdell, J. Goldstein
- MedicineJournal of clinical pharmacology
- 1 January 2003
Tlbutamide is a better CYP2C9 probe than flurbiprofen and losartan, and the 0‐ to 12‐hour amount of 4'‐hydroxytolbutamide and carboxytol butamide is the best urinary measure of its metabolism.
CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study
- Craig R. Lee, K. North, M. Bray, D. Couper, G. Heiss, D. Zeldin
- Medicine, BiologyPharmacogenetics and genomics
- 1 May 2007
The G-50T polymorphism in CYP2J2 may be an important risk factor for the development of coronary heart disease events in African-Americans, whereas cigarette smoking may modify the relationship between the I264M and K399R polymorphisms in CYp2C8 and coronaryHeart disease risk in Caucasians.
Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension‐induced renal injury in mice
- Craig R. Lee, J. Imig, D. Zeldin
- Biology, MedicineFASEB journal : official publication of the…
- 1 October 2010
It is concluded that endothelial CYP epoxygenase function contributes to the regulation of blood pressure and renal injury in mice.