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Meiotic recombination in S. cerevisiae is initiated by double-strand breaks (DSBs). In certain mutants, breaks accumulate with a covalently attached protein, suggesting that cleavage is catalyzed by the DSB-associated protein via a topoisomerase-like transesterase mechanism. We have purified these protein-DNA complexes and identified the protein as Spo11,(More)
Biclustering algorithms have been successfully used to find subsets of co-expressed genes under subsets of conditions. In some cases, microarray experiments are performed to compare the biological activities of the genes between two classes of cells, such as normal and cancer cells. In this paper, we propose <i>DiBiCLUS</i>, a novel <b>Di</b>fferential(More)
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