Craig Michie

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The lifespan of thymic-derived or T lymphocytes is of particular interest because of their central role in immunological memory. Is the recall of a vaccination or early infection, which may be demonstrated clinically up to 50 years after antigen exposure, retained by a long-lived cell, or by its progeny? Using the observation that T lymphocyte expression of(More)
Patients with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) typically have a high HTLV-1 proviral load in peripheral blood mononuclear cells and abundant, activated HTLV-1-specific cytotoxic T lymphocytes (CTLs). No effective treatment for HAM/TSP has been described so far. We report a 10-fold(More)
Arstila et al. (1) estimated an average diversity of 9 ϫ 10 5 different ␤ chains and 4.5 ϫ 10 5 different ␣ chains in the human naı¨ve T cell repertoire. To calculate the total T cell repertoire diversity, the ␤-chain diversity was estimated within a certain variable (V) gene family, V ␣ 12 ϩ , comprising 2.5% of the total ␣-chain repertoire. Finding in(More)
We propose a novel scheme to realize multicast based on our previously reported carrier-reuse WDM-PON architecture. The subcarriers are employed to transmit the downlink point-to-point (unicast) data, whereas the carriers of the downlink subcarrier modulated lights are reused by the reflective semiconductor optical amplifiers at each optical network unit(More)
Passive optical networks are being aggressively pursued as a means of delivering access network solutions. The cost benefits resulting from reducing the number of interfaces between nodes has enabled increasing deployment of passive optical network delivering fibre to the home and fibre to the kerb. However, in many cases, the need for high split ratios or(More)
We report on a monolithic adjustable gain clamped semiconductor optical amplifier (AGC-SOA). The device consists of 2 tuneable gratings and a gain section and enables the gain of the SOA to be regulated without loss of saturated output power. Gain control is achieved by adjusting the wavelength overlap of two Distributed Bragg Reflector gratings positioned(More)