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Anticancer agents from the Australian tropical rainforest: Spiroacetals EBC-23, 24, 25, 72, 73, 75 and 76.
The novel spiroacetal structural motif, exemplified by EBC-23 (1), was found to inhibit the growth of the androgen-independent prostate tumor cell line DU145 in the mouse model, indicating potential for the treatment of refractory solid tumors in adults.
Stachyonic Acid: A Dengue Virus Inhibitor from Basilicum polystachyon.
Stachyonic acid A, arising from the first in-depth phytochemical investigation of the herb Basilicum polystachyon, was found to display potent inhibitory activity against dengue virus, with limited
Total synthesis of (+/-)-5,14-bis-epi-spirovibsanin A.
Physical data obtained from (+/-)-5,14-bis-epi-spirovibsanin A lends strong support to the proposed connectivity and relative stereochemistry of spirovibertsin A.
Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon.
The highly oxygenated pimarane diterpenoids basimarols A, B, and C (3-5) were isolated from the plant species Basilicum polystachyon and revealed broad spectrum antiviral activity against West Nile virus and human influenza viruses H1N1 and H3N2.
An improved preparation of phorbol from croton oil
The isolation of phorbol from croton oil is dangerous Because of the toxic properties of the oil, poorly reproducible because of differences in its phorboid profile, and time-consuming because of the capricious final crystallization step.
Salmonella typhimurium U290 outbreak linked to a bakery.
This report summarises the investigation of the first documented outbreak of Salmonella Typhimurium Phage type U290 exhibiting tetracycline resistance. (non-author abstract)
Pharmaceuticals that contain polycyclic hydrocarbon scaffolds.
This review highlights approximately 20 all carbon cage containing pharmaceuticals, ranging in structure from bicyclo[2.2.1] through to adamantane, including some in the top-selling pharmaceutical bracket.