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Previous reports have indicated that alpha-MSH release inhibiting hormone (MIF-1) increased the behavior occurring as a result of the dihydroxyphenylalanine (DOPA) potentiation test [3,7]. This study was undertaken to see whether dopamine (DA) or norepinephrine (NE) levels likewise increased in the test animals. The DOPA potentiation test was performed as(More)
The Purkinje target cells for noradrenergic fibers originating in the locus coeruleus are considered to be of importance in the regulation of noradrenergic input to the cerebellum. The availability of a mouse mutant, Purkinje cell degeneration provides a non-surgical means for studying cellular regulation of innervation. Using a glyoxylic acid(More)
In order to demonstrate the influence of morphine on the developmental localization of regenerated noradrenergic fibers in rat cerebellum, a glyoxylic histofluorescent method and radiometric assay for norepinephrine (NE) were utilized. An initial reduction of NE in the cerebellum after 6-hydroxydopa [6-OHDOPA; 60 micrograms/g intraperitoneally (i.p.)] was(More)
Because endorphin receptor activation alters the function of the central noradrenergic system, opiates may change the regenerative sprouting of neurons in response to adrenergic neurotoxins. To test this hypothesis, newborn rats were treated with several opioids and 6-hydroxydopa (6-OHDOPA) and the development of the noradrenergic system was evaluated. In(More)
Treatment of newborn rats with 6-hydroxydopa (6-OHDOPA, 60 micrograms/g IP) increased the levels of norepinephrine in the adult cerebellum and hindbrain. Concurrent treatment with morphine sulfate (20 micrograms/g IP) potentiated the response to 6-OHDOPA in the cerebellum and pons-medulla. In addition, increased noradrenergic neurite density in 4 week(More)
Several seemingly conflicting sets of data have been reported on the regenerative capacity of central noradrenergic neurons, following transection of the ascending noradrenergic fiber tract in neonatal rats (Iacovitti et al., Dev Brain Res 1: 21-33, 1981; Jonsson and Sachs, Brain Res Bull 9: 641-650, 1982). In order to more fully investigate changes in(More)
Aeronautics and Space (administration (NASA) Contract #NAS13–435. The data was supplied by Middle Tennessee State University Center for Remote Sensing. ABSTRACT Neural networks classified a thematic mapper LandSat 4 multi-spectral image of the area surrounding Murfree=boroS Tennessee. Back propagation neural network= were trained to identify different land(More)