Craig E. Wheelock

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Trials and tribulations of 'omics data analysis: assessing quality of SIMCA-based multivariate models using examples from pulmonary medicine.

Åsa M. Wheelock, Craig E. Wheelock
Molecular bioSystems
2013

Respiratory diseases are multifactorial heterogeneous diseases that have proved recalcitrant to understanding using focused molecular techniques. This trend has led to the rise of 'omics approaches… (More)

Structural refinement of inhibitors of urea-based soluble epoxide hydrolases.

Christophe H P Morisseau, Marvin H. Goodrow, John W. Newman, Craig E. Wheelock, Deanna L Dowdy, Bruce D Hammock
Biochemical pharmacology
2002

The soluble epoxide hydrolase (sEH) is involved in the metabolism of arachidonic, linoleic, and other fatty acid epoxides, endogenous chemical mediators that play an important role in blood pressure… (More)

Applications of carboxylesterase activity in environmental monitoring and toxicity identification evaluations (TIEs).

Craig E. Wheelock, Bryn M. Phillips, Brian S. Anderson, Jeff L. Miller, Mike J Miller, Bruce D Hammock
Reviews of environmental contamination and…
2008

This review has examined a number of issues surrounding the use of carboxylesterase activity in environmental monitoring. It is clear that carboxylesterases are important enzymes that deserve… (More)

Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos.

Craig E. Wheelock, Kai J. Eder, +5 authors Bruce D Hammock
Aquatic toxicology
2005

Acetylcholinesterase (AChE) activity has traditionally been monitored as a biomarker of organophosphate (OP) and/or carbamate exposure. However, AChE activity may not be the most sensitive endpoint… (More)

Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes.

Jeanette E Stok, Huazhang Huang, Paul D Jones, Craig E. Wheelock, Christophe H P Morisseau, Bruce D Hammock
The Journal of biological chemistry
2004

Carboxylesterases are enzymes that catalyze the hydrolysis of a wide range of ester-containing endogenous and xenobiotic compounds. Although the use of pyrethroids is increasing, the specific enzymes… (More)

Synthesis Challenges in Regulating Pesticide Mixtures

This paper introduces the field of mixture toxicity and the challenges in regulating pesticide mixtures. Even though pesticides are unique chemical stressors designed to have biological activity that… (More)

Development of toxicity identification evaluation procedures for pyrethroid detection using esterase activity.

Craig E. Wheelock, Jeff L. Miller, Mike J Miller, Shirley J. Gee, Guomin Shan, Bruce D Hammock
Environmental toxicology and chemistry
2004

Recent agrochemical usage patterns suggest that the use of organophosphate (OP) pesticides will decrease, resulting in a concomitant increase in pyrethroid usage. Pyrethroids are known for their… (More)

Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD.

David Balgoma, Mingxing Yang, +13 authors Craig E. Wheelock
The European respiratory journal
2016

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality; however, the role of inflammatory mediators in its pathobiology remains unclear. The aim of this study was to investigate… (More)

Systems biology approaches and pathway tools for investigating cardiovascular disease.

Craig E. Wheelock, Åsa M. Wheelock, +6 authors Susumu Goto
Molecular bioSystems
2009

Systems biology aims to understand the nonlinear interactions of multiple biomolecular components that characterize a living organism. One important aspect of systems biology approaches is to… (More)

Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration.

Julia Esser, Ulf Gehrmann, +5 authors Olof Rådmark
The Journal of allergy and clinical immunology
2010

BACKGROUND Leukotrienes (LTs) are potent proinflammatory lipid mediators with key roles in the pathogenesis of asthma and inflammation. Recently, nanovesicles (exosomes), released from macrophages… (More)

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