Craig A. Swearingen

Louis J Bedell1
Susan Carol Howard1
Daniel Becker1
Joseph J Mcdonald1
1Louis J Bedell
1Susan Carol Howard
1Daniel Becker
1Joseph J Mcdonald
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  • Daniel Becker, Clara I Villamil, Thomas E Barta, Louis J Bedell, Daniel Becker, Daniel P Becker +13 others
  • 2016
α-Piperidine-β-sulphone hydroxamates were explored that are potent for MMP-2,-9 and-13 that are sparing of MMP-1 with good pk in the rat. An unexpected decarbonylation led to the hitherto unknown and α-sulphone hydroxamates that are superior to the corresponding β-sulphones in potency for target MMP's, selectivity versus MMP-1, and oral exposure when dosed(More)
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