Craig A. Obafemi

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A simple and efficient method has been developed for the synthesis of various 2-quinoxalinone-3-hydrazone derivatives using microwave irradiation technique. The series of 2-quinoxalinone-3-hydrazone derivatives synthesized, were structurally confirmed by analytical and spectral data and evaluated for their antimicrobial activities. The results showed that(More)
A series of novel quinoxalin-2(1H)-one-3-hydrazone derivatives, 2a 8d were synthesized via condensation of 3-hydrazinoquinoxalin-2(1H)-one, 1, with the corresponding ketones under microwave irradiation. The microwave assisted reaction was remarkably successful and gave hydrazones in higher yield at less reaction time compared to conventional heating method.(More)
2,3-Dichloroquinoxaline and some of its derivatives have been reacted with malononitrile and ethyl cyanoacetate to yield a variety of 3-chloro-2-(cyanomethylene)- 1,2-dihydroquinoxaline derivatives. The reaction of 3-chloro-2-(dicyanomethylene)-1,2- dihydroquinoxaline (2e) with pyridine and its methyl derivatives led to the zwitterionic structures 6a-6c.(More)
3-Hydrazinoquinoxalin-2(1H)-one was prepared from quinoxaline-2,3-dione and subsequently used for the synthesis of some potentially biologically active 3-(pyrazol-1-yl)quinoxalin-2(1H)-one derivatives. While 3-(3,5-dimethylpyrazol-1-yl)quinoxalin-2(1H)-one showed a comparative effect with streptomycin,(More)
In the title compound, C(22)H(24)N(2)O(2)·H(2)O, the co-crystallized water mol-ecule inter-acts with the N and O atoms of the mol-ecule through O(w)-H⋯N, O(w)-H⋯O(meth-yl) and N-H⋯O(w) hydrogen-bonding inter-actions. These hydrogen bonds, along with the inter-molecular N-H⋯O=C hydrogen-bonding inter-actions, connect the mol-ecules into a three-dimensional(More)
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