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Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications
TLDR
The high-resolution crystal structure of the carboxy-terminal deaminase domain of APOBEC3G (APOBec3G-CD2) purified from Escherichia coli is reported, and residues involved in substrate specificity, single-stranded DNA binding and deaminases activity are identified. Expand
The APOBEC-2 crystal structure and functional implications for the deaminase AID
TLDR
The crystal structure of APO2 is reported and it is shown that AID deamination activity is impaired by mutations predicted to interfere with oligomerization and substrate access, resulting in defective antibody maturation. Expand
Structural Model for Deoxycytidine Deamination Mechanisms of the HIV-1 Inactivation Enzyme APOBEC3G*♦
TLDR
A structure-based model is proposed to explain the scanning and catalytic behavior of Apo3G, a single-stranded DNA-dependent deoxycytidine deaminase, which, in the absence of the human immunodeficiency virus, is encapsulated into HIV virions. Expand
The current structural and functional understanding of APOBEC deaminases
TLDR
A detailed structural analysis of the APOBEC proteins and a comparison to other zinc-coordinating deaminases can facilitate the understanding of how APOBec proteins bind nucleic acids, recognize substrates, and form oligomers. Expand
A systematic study of the N-glycosylation sites of HIV-1 envelope protein on infectivity and antibody-mediated neutralization
TLDR
This report provides the first systematic experimental account of the biological role of the entire PNGS on an HIV-1 Env, which should provide valuable insights for understanding the function of Env in HIV infection cycle and for developing future anti-HIV strategies. Expand
APOBEC deaminases-mutases with defensive roles for immunity
TLDR
This review provides an overview of recent advances in structural and functional studies of the APOBEC enzymes and provides new biochemical insights for how these enzymes carry out their biological roles. Expand
A Structural Basis for the Biochemical Behavior of Activation-induced Deoxycytidine Deaminase Class-switch Recombination-defective Hyper-IgM-2 Mutants*
TLDR
A series of C-terminal deletion mutants are constructed that retain catalytic activity and processivity for deletions ≤18 amino acids, with ΔC10 and ΔC15 having 2–3-fold higher specific activities than WT AID. Expand
Lentivirus restriction by diverse primate APOBEC3A proteins.
Rhesus macaque APOBEC3A (rhA3A) is capable of restricting both simian-human immunodeficiency virus (SHIVΔvif) and human immunodeficiency virus (HIV-1Δvif) to a greater extent than hA3A. WeExpand
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