Courtney Kathryn Robinson

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Oxidative stress occurs when the generation of reactive oxygen species (ROS) exceeds the capacity of the cell's endogenous systems to neutralize them. Our analyses of the cellular damage and oxidative stress responses of the archaeon Halobacterium salinarum exposed to ionizing radiation (IR) revealed a critical role played by nonenzymatic antioxidant(More)
Complexity of cellular response to oxidative stress (OS) stems from its wide-ranging damage to nucleic acids, proteins, carbohydrates, and lipids. We have constructed a systems model of OS response (OSR) for Halobacterium salinarum NRC-1 in an attempt to understand the architecture of its regulatory network that coordinates this complex response. This has(More)
BACKGROUND The Atacama Desert is one of the driest deserts in the world and its soil, with extremely low moisture, organic carbon content, and oxidizing conditions, is considered to be at the dry limit for life. RESULTS Analyses of high throughput DNA sequence data revealed that bacterial communities from six geographic locations in the hyper-arid core(More)
Ionizing radiation (IR) is of particular interest in biology because its exposure results in severe oxidative stress to the cell’s macromolecules. Our recent work with extremophiles supports the idea that IR resistance is most likely achieved by a metabolic route, effected by manganese (Mn) antioxidants. Biochemical analysis of “super-IR resistant” mutants(More)
The Atacama Desert is one of the oldest and driest deserts in the world, and its hyper-arid core is described as 'the most barren region imaginable'. We used a combination of high-throughput sequencing and microscopy methods to characterize the endolithic microbial assemblages of halite pinnacles (salt rocks) collected in several hyper-arid areas of the(More)
PURPOSE In the past decade, remarkable relationships have been documented between dysbiosis of the human microbiota and adverse health outcomes. This review seeks to highlight some of the challenges and pitfalls that may be encountered during all stages of microbiota research, from study design and sample collection, to nucleic acid extraction and(More)
Under extreme water deficit, endolithic (inside rock) microbial ecosystems are considered environmental refuges for life in cold and hot deserts, yet their diversity and functional adaptations remain vastly unexplored. The metagenomic analyses of the communities from two rock substrates, calcite and ignimbrite, revealed that they were dominated by(More)
Title of Document: RESISTANCE TO IONIZING RADIATION AND OXIDATIVE STRESS IN HALOBACTERIUM SALINARUM NRC-1 Courtney Kathryn Robinson, Master of Science, 2009 Directed By: Professor Jonathan Dinman, Department of Cell Biology and Molecular Genetics Oxidative stress results from environmental challenges that cause unchecked production of reactive oxygen(More)
3 Alexander Crits-Christoph, Courtney K. Robinson, Bing Ma, Jacques Ravel, Jacek 4 Wierzchos, Carmen Ascaso, Octavio Artieda, Virginia Souza-Egipsy, M. Cristina 5 Casero and Jocelyne DiRuggiero 6 Biology Department, The Johns Hopkins University, Baltimore, MD, USA; Institute for 7 Genome Sciences, University of Maryland School of Medicine, Baltimore, MD,(More)
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