Costas P. Exarchos

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OBJECTIVE In the current work we propose a methodology for the automated creation of fuzzy expert systems, applied in ischaemic and arrhythmic beat classification. METHODS The proposed methodology automatically creates a fuzzy expert system from an initial training dataset. The approach consists of three stages: (a) extraction of a crisp set of rules from(More)
In protein structures the peptide bond is found to be in trans conformation in the majority of the cases. Only a small fraction of peptide bonds in proteins is reported to be in cis conformation. Most of these instances (>90%) occur when the peptide bond is an imide (X-Pro) rather than an amide bond (X-nonPro). Due to the implication of cis/trans(More)
Oral squamous cell carcinoma (OSCC) constitutes the predominant neoplasm of the head and neck region, featuring particularly aggressive nature, associated with quite unfavorable prognosis. In this paper, we formulate a decision support system that integrates a multitude of heterogeneous data (clinical, imaging, and genomic), thus, framing all manifestations(More)
Fold recognition is a challenging field strongly associated with protein function determination, which is crucial for biologists and the pharmaceutical industry. Hidden Markov models (HMMs) have been widely used for this purpose. In this paper we demonstrate how the fold recognition performance of a recently introduced HMM with a reduced state-space(More)
Polypeptides are composed of amino acids covalently bonded via a peptide bond. The majority of peptide bonds in proteins is found to occur in the trans conformation. In spite of their infrequent occurrence, cis peptide bonds play a key role in the protein structure and function, as well as in many significant biological processes. We perform a systematic(More)
In peptides and proteins, only a small percentile of peptide bonds adopts the cis configuration. Especially in the case of amide peptide bonds, the amount of cis conformations is quite limited thus hampering systematic studies, until recently. However, lately the emerging population of databases with more 3D structures of proteins has produced a(More)
PBOND is a web server that predicts the conformation of the peptide bond between any two amino acids. PBOND classifies the peptide bonds into one out of four classes, namely cis imide (cis-Pro), cis amide (cis-nonPro), trans imide (trans-Pro) and trans amide (trans-nonPro). Moreover, for every prediction a reliability index is computed. The underlying(More)
Oral cancer is the predominant neoplasm of the head and neck. Annually, more than 500.000 new cases of oral cancer are reported, worldwide. After the initial treatment of cancer and its complete disappearance, a state called remission, reoccurrence rates still remain quite high and the early identification of such relapses is a matter of great importance.(More)
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