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OBJECTIVE To evaluate the 24-hour efficacy of brimonidine purite versus dorzolamide, each added to latanoprost. DESIGN Double-masked, 2-center, prospective, crossover comparison. PARTICIPANTS Primary open-angle glaucoma (POAG) subjects. METHODS Subjects were randomized to brimonidine purite or dorzolamide, each given twice daily, for the first 6-week(More)
AIMS To evaluate intra- and interobserver variability in measurements on normal and astigmatic corneas with keratometry and computerized videokeratography. METHODS Keratometric readings with the 10 SL/O Zeiss keratometer and topographic maps with the TMS-1 were obtained by two independent examiners on 32 normal and 33 postkeratoplasty corneas. Inter- and(More)
Pellucid marginal corneal degeneration (PMCD) is an uncommon cause of inferior peripheral corneal ectasia, affecting patients between the ages of 20 and 40 years. Although histopathologically it is considered a variant of keratoconus, it differs in that the marked corneal steepening occurs more inferiorly, above a narrow band of corneal stromal thinning(More)
The association between retinopathy in type 2 diabetes [diabetic retinopathy (DR)] and the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene has been investigated in several case-control studies. These studies rendered contradictory results, some indicating that the polymorphism is associated with the risk of developing DR whereas(More)
PURPOSE To evaluate agreement in measurements of astigmatic axis power and location between keratometry and computer assisted videokeratography (corneal topography) on normal corneas with less than 1.50 D of idiopathic astigmatism. METHODS Keratometric readings with the 10 SL/O Zeiss ophthalmometer and corneal topographic maps with the TMS-1 were obtained(More)
Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare entity first described in 1975, affecting mainly young women and adolescents. We present a case of a 52-year-old female patient (one of the oldest in the literature) who complained of fever, anorexia, nausea, and vomiting. After she was admitted to our hospital, laboratory tests revealed(More)
OBJECTIVE To assess the effectiveness of computerized videokeratography (CVK) in refining the surgical design and in improving predictability of surgical correction of postkeratoplasty astigmatism. DESIGN A prospective, controlled, randomized, clinical trial. PARTICIPANTS A total of 31 postkeratoplasty eyes, divided into 2 groups (group A, 16 eyes;(More)
PURPOSE Carbomer gel is a water-soluble polymeric resin that has been reported to maintain the tear film in contact with the eye for an extended period. The efficacy and safety of this new artificial tear were assessed. METHODS A multicenter, single-masked, randomized, placebo-controlled study was carried out on 123 patients with moderate-to-severe dry(More)
OBJECTIVE To compare postoperative astigmatism induced by two different suturing techniques in penetrating keratoplasty (PKP). DESIGN A monocenter, prospective, randomized clinical trial with a longitudinal 1-year follow-up. PARTICIPANTS A total of 95 eyes undergoing PKP were randomized into 2 groups. Of these, 51 eyes were allocated to the combined(More)
The aim of the present study was to evaluate the effect of latanoprost monotherapy on the aqueous humour concentrations of TGF-beta1, MMP-2, TIMP-2, MMP-9 and gelatinolytic activity in patients treated for exfoliative glaucoma (XFG). Aqueous samples from 50 XFG patients treated with latanoprost and 50 age-matched XFG patients treated with timolol were(More)