Cosmin Lisencu

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Introduction. Colorectal cancer (CRC) is an important cause of morbidity and mortality worldwide. Angiogenesis was reported as one important mechanism activated in colorectal carcinogenesis. Tumor microenvironment associated angiogenesis involves a large spectrum of signaling molecules and deciphering their role in colorectal carcinogenesis still represents(More)
BACKGROUND AND AIMS The aim of this study was to investigate the value of serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA 19-9) correlated with some tissue molecules as predictive markers for recurrence in colon cancer. METHODS A total of 30 patients diagnosed with colon cancer stage II or III who underwent optimal surgery were enrolled(More)
Marginal zone lymphoma is a heterogeneous category of indolent non-Hodgkin lymphomas (NHLs). Splenic marginal zone lym-phoma (SMZL) represent 2% of lymphoid neoplasia. 1 Epidemio-logic studies have linked this category of NHLs to several agents capable of establishing chronic infections in humans. 2 Hepatitis C virus (HCV) infection has been linked(More)
Colorectal cancer is the third most common cancer in the world and considered to be one of the most diet-related types of cancer. Extensive research has been conducted but still the link between diet and colorectal cancer is complex. Recent studies have highlight microRNAs (miRNAs) as key players in cancer-related pathways in the context of dietary(More)
Thyroid carcinoma (TC) is the most common endocrine malignancy. Although the overall prognosis for patients with TC is good, up to 20-30% of patients have recurrent or persistent disease after conventional therapy by surgical resection and radioactive iodine (RAI). Amiodarone is a highly efficient anti-arrhythmic drug with a very long half-life, so it may(More)
BACKGROUND AND AIM Ketamine is a drug used for the induction and maintenance of general anesthesia, for the treatment of postoperative and posttraumatic acute pain, and more recently, for the reduction of postoperative opioid requirements. The main mechanism of action of ketamine is the antagonization of N-methyl-D-aspartate (NMDA) receptors that are(More)
BACKGROUND AND AIMS Castleman's disease is a rare disorder situated at the boundary between reactive and neoplastic conditions. The pathogenesis is a subject of debate and the limited number of cases renders the study of the disease difficult. In our paper we present a series of six cases of Castleman disease with emphasis on the clinical presentation,(More)
UNLABELLED Primary neuroendocrine cancer of the breast (NECB) is an extremely rare tumor. In 2003, the World Health Organization (WHO) recognized this category with three well-described subtypes: small cell, large cell, and carcinoid-like carcinoma; very few peer-review publications based on the WHO definition were encountered in the literature, and we(More)
Objective: To practice evidence-based medicine a core set of concepts must be mastered. Recognizing this, we sought to develop and assess a mini-course in evidence-based medicine for fourth-year medical students. Design: A two-hour curriculum on evidence-based medicine training was developed and applied on a sample of fifty-five fourth-year medical(More)
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