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Arachidonic Acid-metabolizing Cytochrome P450 Enzymes Are Targets of ω-3 Fatty Acids*
- Cosima Arnold, Marija Marković, +9 authors Wolf-Hagen Schunck
- Biology, Medicine
- The Journal of Biological Chemistry
- 23 August 2010
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) protect against cardiovascular disease by largely unknown mechanisms. We tested the hypothesis that EPA and DHA may compete with arachidonic… Expand
Cytochrome P450-dependent metabolism of omega-6 and omega-3 long-chain polyunsaturated fatty acids.
Dietary fish oil omega-3 fatty acids (n-3 PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), protect against arrhythmia and sudden cardiac death using largely unknown… Expand
Inhibition of 20-HETE synthesis and action protects the kidney from ischemia/reperfusion injury.
20-Hydroxyeicosatetraenoic acid (20-HETE) production is increased in ischemic kidney tissue and may contribute to ischemia/reperfusion (I/R) injury by mediating vasoconstriction and inflammation. To… Expand
Cytochrome P450-dependent metabolism of ω-6 and ω-3 long-chain polyunsaturated fatty acids
Dietary fish oil ω-3 fatty acids (n-3 PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), protect against arrhythmia and sudden cardiac death using largely unknown mechanisms.… Expand
17(R),18(S)-epoxyeicosatetraenoic acid, a potent eicosapentaenoic acid (EPA) derived regulator of cardiomyocyte contraction: structure-activity relationships and stable analogues.
- J. Falck, G. Wallukat, +7 authors Wolf-Hagen Schunck
- Medicine, Chemistry
- Journal of medicinal chemistry
- 23 June 2011
17(R),18(S)-epoxyeicosatetraenoic acid [17(R),18(S)-EETeTr], a cytochrome P450 epoxygenase metabolite of eicosapentaenoic acid (EPA), exerts negative chronotropic effects and protects neonatal rat… Expand
Cytochrome P 450-dependent metabolism of-6 and-3 long-chain polyunsaturated fatty acids
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